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Laboratory of Mass Spectrometry operates as a division of the Biophysics Department of the Institute of Biochemistry and Biophysics since 2001. It was founded thanks to polish Ministry of Science and Education grants with the aim to support polish biomedical sciences community with the proteomic core facility, which would provide accessible service in terms of protein identification and quantitation, identification and localization of posttranslational modifications, etc. At first, equipped with one Q-ToF spectrometer, the Laboratory staff implemented all necessary procedures, started collaboration in a set of biomedically oriented projects and opened a proteomic service.

In the next years, with growing demand for the types of the analysis offered, confirmed by up to two thousands of commisioned samples per year, the Laboratory undergoes a rapid development. Both in terms of developing new procedures for data collection and analysis and in terms of installing new equipment. Due to several grants: from the Science and Technology Fund of the Ministry of Science and Education, from MILAB program of the Foundation for Polish Science, and CEPT and NanoFUN programs supported by European Union, the instrumentation and the data analysis software available in the Lab could follow the fast development observed in the area of biologically oriented mass spectrometry in recent years. The Lab could thus provide analyses characterized by the best sensitivity available at the moment.

Apart from providing proteomic service the Lab participated in a number of scientific projects from a wide range of areas, which follows the versatile character of proteomic analyses proving useful in wide range of studies. The Laboratory is also involved in the development of new informatic tools for data analysis, as lack of proper, automated tools severely hampers the in-depth analysis of large proteomic datasets. The new informatic tools streamline the analysis of the differential proteomics experiments and ensure proper statistical analysis of obtained results greatly decreasing the number of false positive hits. Another area of interest of the Laboratory is the application of mass spectrometry for protein structure analysis. We have worked out new protocols and new software for monitoring the kinetics of hydrogen-deuterium exchange of protein amide protons and implemented ion mobility spectrometry (IMS) for characterization the collisional cross-section of molecules of interest.

Recently the activity of the Lab was expanded, the new Drug and Metabollites Analysis division of the Lab was founded and new projects on immunosuppressing drugs and their metabolites were started. In this way the area of interest of the lab extends at present beyond proteomics, covering also the area of small-molecule quantitative and qualitative analysis. At present 12 mass spectrometers are being used in the Lab, localized in ca. 600 sq.m. of well equipped lab space.